DC Field | Value | Language |
---|---|---|
dc.contributor.author | PARK, SUNG WOON | - |
dc.contributor.author | LEE, SEUNGHYUN | - |
dc.contributor.author | CHA, WON CHUL | - |
dc.contributor.author | HUR, KYU YEON | - |
dc.contributor.author | KIM, JAE HYUN | - |
dc.contributor.author | LEE, MOON-KYU | - |
dc.contributor.author | PARK, SUNG-MIN | - |
dc.contributor.author | JIN, SANG-MAN | - |
dc.date.accessioned | 2020-02-27T00:51:40Z | - |
dc.date.available | 2020-02-27T00:51:40Z | - |
dc.date.created | 2020-02-25 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/101223 | - |
dc.description.abstract | Background: We aimed to describe the outcome of a computerized intravenous insulin infusion (CII) protocol integrated to the electronic health record (EHR) system and to improve the CII protocol in silico using the EHR-based predictors of the outcome. Methods: Clinical outcomes of the patients who underwent the CII protocol between July 2016 and February 2017 and their matched controls were evaluated. In the CII protocol group (n =91), multivariable binary logistic regression analysis models were used to determine the independent associates with a delayed response (taking >= 6.0 hours for entering a glucose range of 70 to 180 mg/dL). The CII protocol was adjusted in silico according to the EHR-based parameters obtained in the first 3 hours of CII. Results: Use of the CII protocol was associated with fewer subjects with hypoglycemia alert values (P=0.003), earlier (P=0.002), and more stable (P=0.017) achievement of a glucose range of 70 to 180 mg/dL. Initial glucose level (P=0.001), change in glucose during the first 2 hours (P=0.026), and change in insulin infusion rate during the first 3 hours (P= 0.029) were independently associated with delayed responses. Increasing the insulin infusion rate temporarily according to these parameters in silico significantly reduced delayed responses (P < 0.0001) without hypoglycemia, especially in refractory patients. Conclusion: Our CII protocol enabled faster and more stable glycemic control than conventional care with minimized risk of hypoglycemia. An EHR-based adjustment was simulated to reduce delayed responses without increased incidence of hypoglycemia. | - |
dc.language | English | - |
dc.publisher | KOREAN DIABETES ASSOC | - |
dc.relation.isPartOf | DIABETES & METABOLISM JOURNAL | - |
dc.title | An Electronic Health Record-Integrated Computerized Intravenous Insulin Infusion Protocol: Clinical Outcomes and in Silico Adjustment | - |
dc.type | Article | - |
dc.identifier.doi | 10.4093/dmj.2018.0227 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, v.44, no.1, pp.56 - 66 | - |
dc.identifier.kciid | ART002561292 | - |
dc.identifier.wosid | 000517786100006 | - |
dc.citation.endPage | 66 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 56 | - |
dc.citation.title | DIABETES & METABOLISM JOURNAL | - |
dc.citation.volume | 44 | - |
dc.contributor.affiliatedAuthor | LEE, SEUNGHYUN | - |
dc.contributor.affiliatedAuthor | PARK, SUNG-MIN | - |
dc.identifier.scopusid | 2-s2.0-85080865090 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PERIOPERATIVE GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | ARTIFICIAL PANCREAS | - |
dc.subject.keywordPlus | GLUCOSE CONTROL | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CARE | - |
dc.subject.keywordPlus | HYPOGLYCEMIA | - |
dc.subject.keywordPlus | HYPERGLYCEMIA | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Computer simulation | - |
dc.subject.keywordAuthor | Electronic health records | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | Medical records systems | - |
dc.subject.keywordAuthor | computerized | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
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