Synthesis of myo-Inositol-1,4,5-2,4,6-and 1,3,5-trisphosphate
- Title
- Synthesis of myo-Inositol-1,4,5-2,4,6-and 1,3,5-trisphosphate
- Authors
- CHANG, YOUNG TAE; Chung, Sung-Kee; Sohn, Kwang-Hoon
- Date Issued
- 1994-02
- Publisher
- Korean Chemical Society
- Abstract
- myo-Inosiol-1,4,5-trisphosphate(1) is well established as a second messenger mobilizing Ca2+ in the intracellular signal transduction pathway. Compound 1 and its positional isomers, myo-Inositol 2,4,6-trisphosphate(2) and -1,3,5-trisphosphate(3) were synthesized from myo-inositol. An efficient synthetic pathway of 1 using myo-inositol-1,2,4-trisbenzoate(6) as the key intermediate, prepared from myo-inositol-1,4-bisbenzoate(5) by regioselective benzoylation at the axial 2-OH over the eqiuatorial 3-OH, is described. Syntheses of 2 and 3 utilizing the monoorthoformate derivative(8) of myo-inositol as the key intermediate are also reported.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/101528
- ISSN
- 1017-2548
- Article Type
- Article
- Citation
- Journal of the Korean Chemical Society, vol. 4, no. 1, page. 57 - 65, 1994-02
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- There are no files associated with this item.
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