Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy
SCIE
SCOPUS
- Title
- Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy
- Authors
- Li, Xingshu; Park, Eun-Yeong; Kang, Youngnam; Kwon, Nahyun; Yang, Mengyao; Lee, Seunghyun; Kim, Won Jong; Kim, Chulhong; Yoon, Juyoung
- Date Issued
- 2020-03
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging-guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self-assembly of two water-soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4-PcN4) and consequently enables the fabrication of PcS4-PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4-PcN4. In vivo evaluations suggest that PcS4-PcN4 could not only efficiently visualize a tumor with high contrast through whole-body photoacoustic imaging but also enable excellent photothermal therapy for cancer.
- Keywords
- Diagnosis; Diseases; Fluorescence quenching; Gas generators; Molecular oxygen; Nanostructures; Photoacoustic effect; Cancer diagnosis; High contrast; Nano-structured; Photo-acoustic imaging; Photothermal therapy; phthalocyanine; Phthalocyanine derivatives; Singlet oxygen generation; Supramolecular chemistry
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/103565
- DOI
- 10.1002/anie.201916147
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020-03
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- There are no files associated with this item.
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