DC Field | Value | Language |
---|---|---|
dc.contributor.author | Garcia-Vello, Pilar | - |
dc.contributor.author | Sharma, Garima | - |
dc.contributor.author | Speciale, Immacolata | - |
dc.contributor.author | Molinaro, Antonio | - |
dc.contributor.author | Im, Sin-Hyeog | - |
dc.contributor.author | De Castro, Cristina | - |
dc.date.accessioned | 2020-05-04T09:50:07Z | - |
dc.date.available | 2020-05-04T09:50:07Z | - |
dc.date.created | 2020-03-18 | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/103623 | - |
dc.description.abstract | The capsular material from Lactobacillus plantarum IMB19, an isolate from fermented vegetables, has been analyzed and our results demonstrate that most of the coat of this bacterium consists of glycerol- and ribitol-type teichoic acids, further decorated with other substituents (a-glucose and alanine), and of a capsular polysaccharide (CPS) with a linear nonasaccharide repeating unit, rich in rhamnose, interconnected to the next via a phosphodiester bridge. Stimulation of immune cells with the total capsular material resulted in the enhancement of immunostimulatory (IFN gamma, TNF-alpha, IL-6 and IL-12) or immuno-regulatory (IL-10) cytokines in an in vitro splenocyte culture system. The capsular polysaccharide, and not the teichoic acids mixture, was responsible for the IFN gamma production. Indeed, a significant increase of IFN gamma along with other inflammatory cytokines, and a dose response in IFN. expression with an EC50 of 3.16 mu M was found for CPS, disclosing that this polysaccharide is a potent immunostimulatory molecule. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | CARBOHYDRATE POLYMERS | - |
dc.title | Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum: a novel rhamnose-rich polysaccharide and teichoic acids | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.carbpol.2020.115857 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CARBOHYDRATE POLYMERS, v.233 | - |
dc.identifier.wosid | 000513914400034 | - |
dc.citation.title | CARBOHYDRATE POLYMERS | - |
dc.citation.volume | 233 | - |
dc.contributor.affiliatedAuthor | Sharma, Garima | - |
dc.contributor.affiliatedAuthor | Im, Sin-Hyeog | - |
dc.identifier.scopusid | 2-s2.0-85077922401 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | WALL | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | BACTERIAL | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | PENTOSUS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordAuthor | Capsular polysaccharide | - |
dc.subject.keywordAuthor | Teichoic acid | - |
dc.subject.keywordAuthor | Structure | - |
dc.subject.keywordAuthor | Immunological activity | - |
dc.subject.keywordAuthor | NMR | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
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