DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHAE, SUHUN | - |
dc.contributor.author | SUN, YUCHENG | - |
dc.contributor.author | CHOI, YEONGJIN | - |
dc.contributor.author | HA, DONG HEON | - |
dc.contributor.author | JEON, INHO | - |
dc.contributor.author | CHO, DONG WOO | - |
dc.date.accessioned | 2021-06-15T00:50:22Z | - |
dc.date.available | 2021-06-15T00:50:22Z | - |
dc.date.created | 2021-02-24 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1758-5082 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/106727 | - |
dc.description.abstract | The tendon-bone interface (TBI) in rotator cuffs exhibits a structural and compositional gradient integrated through the fibrocartilaginous transition. Owing to restricted healing capacity, functional regeneration of the TBI is considered a great clinical challenge. Here, we establish a novel therapeutic platform based on 3D cell-printing and tissue-specific bioinks to achieve spatially-graded physiology for functional TBI regeneration. The 3D cell-printed TBI patch constructs are created via a spatial arrangement of cell-laden tendon and bone-specific bioinks in a graded manner, approximating a multi-tissue fibrocartilaginous interface. This TBI patch offers a cell favorable microenvironment, including high cell viability, proliferative capacity, and zonal-specific differentiation of encapsulated stem cells for TBI formation in vitro. Furthermore, in vivo application of spatially-graded TBI patches with stem cells demonstrates their regenerative potential, indicating that repair with 3D cell-printed TBI patch significantly accelerates and promotes TBI healing in a rat chronic tear model. Therefore, our findings propose a new therapeutic strategy for functional TBI regeneration using 3D cell-printing and tissue-specific decellularized extracellular matrix bioink-based approach. | - |
dc.language | English | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.relation.isPartOf | BIOFABRICATION | - |
dc.title | 3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair | - |
dc.type | Article | - |
dc.identifier.doi | 10.1088/1758-5090/abd159 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOFABRICATION, v.13, no.3 | - |
dc.identifier.wosid | 000639512100001 | - |
dc.citation.number | 3 | - |
dc.citation.title | BIOFABRICATION | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | CHAE, SUHUN | - |
dc.contributor.affiliatedAuthor | CHOI, YEONGJIN | - |
dc.contributor.affiliatedAuthor | HA, DONG HEON | - |
dc.contributor.affiliatedAuthor | CHO, DONG WOO | - |
dc.identifier.scopusid | 2-s2.0-85105285293 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | spatial gradient | - |
dc.subject.keywordAuthor | 3D cell-printing | - |
dc.subject.keywordAuthor | rotator cuff | - |
dc.subject.keywordAuthor | tendon-derived decellularized extracellular matrix (TdECM) bioink | - |
dc.subject.keywordAuthor | polyurethane | - |
dc.subject.keywordAuthor | tendon-bone interface | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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