3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair
SCIE
SCOPUS
- Title
- 3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair
- Authors
- CHAE, SUHUN; SUN, YUCHENG; CHOI, YEONGJIN; HA, DONG HEON; JEON, INHO; CHO, DONG WOO
- Date Issued
- 2021-07
- Publisher
- IOP PUBLISHING LTD
- Abstract
- The tendon-bone interface (TBI) in rotator cuffs exhibits a structural and compositional gradient integrated through the fibrocartilaginous transition. Owing to restricted healing capacity, functional regeneration of the TBI is considered a great clinical challenge. Here, we establish a novel therapeutic platform based on 3D cell-printing and tissue-specific bioinks to achieve spatially-graded physiology for functional TBI regeneration. The 3D cell-printed TBI patch constructs are created via a spatial arrangement of cell-laden tendon and bone-specific bioinks in a graded manner, approximating a multi-tissue fibrocartilaginous interface. This TBI patch offers a cell favorable microenvironment, including high cell viability, proliferative capacity, and zonal-specific differentiation of encapsulated stem cells for TBI formation in vitro. Furthermore, in vivo application of spatially-graded TBI patches with stem cells demonstrates their regenerative potential, indicating that repair with 3D cell-printed TBI patch significantly accelerates and promotes TBI healing in a rat chronic tear model. Therefore, our findings propose a new therapeutic strategy for functional TBI regeneration using 3D cell-printing and tissue-specific decellularized extracellular matrix bioink-based approach.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/106727
- DOI
- 10.1088/1758-5090/abd159
- ISSN
- 1758-5082
- Article Type
- Article
- Citation
- BIOFABRICATION, vol. 13, no. 3, 2021-07
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- There are no files associated with this item.
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