DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Changhoon | - |
dc.contributor.author | Choi, Wonseok | - |
dc.contributor.author | Kim, Jeesu | - |
dc.contributor.author | Kim, Chulhong | - |
dc.date.accessioned | 2022-02-28T06:00:28Z | - |
dc.date.available | 2022-02-28T06:00:28Z | - |
dc.date.created | 2021-10-12 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0278-0062 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/109576 | - |
dc.description.abstract | The prevalence of non-alcoholic fatty liver diseases (NAFLD) has increased steadily over the past decade. Thus, diagnosing NAFLD at the earliest stage, which is a reversible condition, has become increasingly important. Here, photothermal strain imaging (pTSI) is presented as a novel non-invasive tool for NAFLD diagnosis. The pTSI uses ultrasound to detect the difference in thermal strain between fat and water during a light-induced temperature rise, which is directly related to the pathological evidence of NAFLD. To demonstrate its feasibility, fat accumulation in in vivo rat livers is monitored non-invasively using pTSI, based on clinical ultrasound B-mode images. A total of 21 male Wistar rats of 3 weeks of age were prepared. Of these, 18 rats received methionine-choline deficient diet for 1 to 6 weeks (n = 3 per week) to induce NAFLD, whereas 3 rats received normal diet as controls (n = 3). Livers were heated by a lipid-sensitive continuous-wave laser, and strain was measured. Quantitative results from the pTSI were compared with histological analysis results using Oil-Red-O (ORO). The receiver operating characteristic curve of in vivo pTSI results for detecting moderate steatosis (ORO-stained area >= 33%) was constructed based on strain change rate measured in the liver region. The sensitivity and specificity of pTSI were 90% and 82%, respectively, and the area-under-the-curve was measured as 0.85 +/- 0.03 (95% confidence interval). The pTSI results tested in the rodent NAFLD model showed great potential for pTSI to be used as a new diagnostic tool for NAFLD in the future. | - |
dc.language | English | - |
dc.publisher | Institute of Electrical and Electronics Engineers | - |
dc.relation.isPartOf | IEEE Transactions on Medical Imaging | - |
dc.title | Non-Invasive Photothermal Strain Imaging of Non-Alcoholic Fatty Liver Disease in Live Animals | - |
dc.type | Article | - |
dc.identifier.doi | 10.1109/TMI.2021.3081097 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | IEEE Transactions on Medical Imaging, v.40, no.9, pp.2487 - 2495 | - |
dc.identifier.wosid | 000692208500026 | - |
dc.citation.endPage | 2495 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2487 | - |
dc.citation.title | IEEE Transactions on Medical Imaging | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Choi, Changhoon | - |
dc.contributor.affiliatedAuthor | Choi, Wonseok | - |
dc.contributor.affiliatedAuthor | Kim, Jeesu | - |
dc.contributor.affiliatedAuthor | Kim, Chulhong | - |
dc.identifier.scopusid | 2-s2.0-85107223551 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACOUSTIC STRUCTURE QUANTIFICATION | - |
dc.subject.keywordPlus | HEPATIC STEATOSIS | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | US | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | VARIABILITY | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | tissue characterization | - |
dc.subject.keywordAuthor | Silicides | - |
dc.subject.keywordAuthor | Platinum alloys | - |
dc.subject.keywordAuthor | Imaging | - |
dc.subject.keywordAuthor | Strain | - |
dc.subject.keywordAuthor | Heating systems | - |
dc.subject.keywordAuthor | Fats | - |
dc.subject.keywordAuthor | Laser beams | - |
dc.subject.keywordAuthor | Photothermal strain imaging | - |
dc.subject.keywordAuthor | preclinical research | - |
dc.subject.keywordAuthor | NAFLD | - |
dc.relation.journalWebOfScienceCategory | Computer Science, Interdisciplinary Applications | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Engineering, Electrical & Electronic | - |
dc.relation.journalWebOfScienceCategory | Imaging Science & Photographic Technology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.