Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars
SCIE
SCOPUS
- Title
- Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars
- Authors
- Jo, H; Youn, H; Lee, S; Ban, C
- Date Issued
- 2014-08-14
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- Although various studies related to nanoparticles-based photothermal therapy have been actively performed, an epoch-making photothermolysis therapy exhibiting both high selectivity and efficiency has yet not been discovered. For the first time, we have developed novel valuable therapeutic complexes, namely, dual aptamer-modified gold nanostars, for the targeting of prostate cancers, including PSMA(+) and PSMA(-) cells. The synthesized probes were characterized through several techniques, including UV-VIS spectral analysis, DLS analysis, zeta potential measurements, and TEM imaging, and were subsequently subjected to cytotoxicity tests, cell uptake confirmation, and in vitro photothermat therapy. The homogeneously well-fabricated nanostars presented high selectivity to prostate cancer cells and extremely high efficiency for therapy using an 808 nm laser under an irradiance of 0.3 W cm(-2), which is lower than the permitted value for skin exposure (0.329 W cm(-2)). It is anticipated that this novel photothermal agent will become the general platform for targeted therapy.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/10989
- DOI
- 10.1039/C4TB00643G
- ISSN
- 2050-750X
- Article Type
- Article
- Citation
- JOURNAL OF MATERIALS CHEMISTRY B, vol. 2, no. 30, page. 4862 - 4867, 2014-08-14
- Files in This Item:
-
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.