Plasmodium vivax: Comparison of the immune responses between oral and parenteral immunization of rPv54 in BALB/c mice
SCIE
SCOPUS
- Title
- Plasmodium vivax: Comparison of the immune responses between oral and parenteral immunization of rPv54 in BALB/c mice
- Authors
- Kwon, Myoung-Hee; Kim, Hyung-Hwan; Lee, Ho-Sa; Kim, Tong-Soo; Oh, Chang-Mi; Ahn, Yong-Joo; Hwang, Seo-Kyong; Sohn, Youngjoo; Kim, Hyuck; Lee, Hyeong-Woo
- Date Issued
- 2010-10
- Publisher
- Academic Press
- Abstract
- The merozoite surface protein-1 (MSP-1) from Plasmodium vivax was evaluated as an oral vaccine candidate by cloning and expressing the interspecies conserved block 10 (ICB10) of the MSP-1 from a Korean isolate in Escherichia coli. The expressed fusion protein contained ICB10 and a maltose-binding protein (MBP), rPv54, has a molecular weight of approximately 54 kDa as determined by SOS-PAGE analysis. IgG against rPv54 was successfully produced in BALB/c mice by oral immunization and sustained for more than 4 months. IgG2b was dominantly produced in both oral and parenteral immunizations. The rPv54 increased the frequency of NK, NKT. CD4+ T, CD8+ T, and B cells in both immunizations. IL-5 and TNF-alpha were increased in both significantly. In conclusion, rPv54 might be a valuable potential vaccine candidate for the oral and parenteral immunization against vivax malaria.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/114584
- DOI
- 10.1016/j.exppara.2010.05.001
- ISSN
- 0014-4894
- Article Type
- Article
- Citation
- Experimental Parasitology, vol. 126, no. 2, page. 217 - 223, 2010-10
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- There are no files associated with this item.
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