DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sun-Young Hwang | - |
dc.contributor.author | Hwa-Young Sun | - |
dc.contributor.author | Kwang-Hoon Lee | - |
dc.contributor.author | Byung-Ha Oh | - |
dc.contributor.author | Yu Jin Cha | - |
dc.contributor.author | Byeang Hyean Kim | - |
dc.contributor.author | Yoo, JY | - |
dc.date.accessioned | 2015-06-25T02:54:12Z | - |
dc.date.available | 2015-06-25T02:54:12Z | - |
dc.date.created | 2015-03-04 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.other | 2015-OAK-0000024742 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11848 | - |
dc.description.abstract | RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFN alpha/beta production. In an attempt to identify novel tools that modulate IFN alpha/beta production, we used SELEX technology to screen RNA aptamers that specifically target RIG-I protein. Most of the selected RIG-I aptamers contained polyU motifs in the second half regions that played critical roles in the activation of RIG-I-mediated IFN beta production. Unlike other known ligands, RIG-I aptamer bound and activated RIG-I in a 5'-triphosphate-independent manner. The helicase and RD domain of RIG-I were used for aptamer binding, but intact RIG-I protein was required to exert aptamer-mediated signaling activation. Furthermore, replication of NDV, VSV and influenza virus in infected host cells was efficiently blocked by pre- or post-treatment with RIG-I aptamer. Based on these data, we propose that RIG-I aptamer has strong potential to be an antiviral agent that specifically boosts the RIG-I-dependent signaling cascade. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | London, Information Retrieval ltd. | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | 5'-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1093/NAR/GKR1098 | - |
dc.author.google | Hwang S.-Y., Sun H.-Y., Lee K.-H., Oh B.-H., Cha Y.J., Kim B.H., Yoo J.-Y. | en_US |
dc.relation.volume | 40 | en_US |
dc.relation.issue | 6 | en_US |
dc.relation.startpage | 2724 | en_US |
dc.relation.lastpage | 2733 | en_US |
dc.contributor.id | 10114821 | en_US |
dc.relation.journal | NUCLEIC ACIDS RESEARCH | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.40, no.6, pp.2724 - 2733 | - |
dc.identifier.wosid | 000302312400036 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2733 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2724 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Yoo, JY | - |
dc.identifier.scopusid | 2-s2.0-84859336804 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 29 | - |
dc.description.scptc | 31 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HEPATITIS-C VIRUS | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | INDUCIBLE GENE-I | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | 5&apos | - |
dc.subject.keywordPlus | -TRIPHOSPHATE RNA | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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