Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
SCIE
SCOPUS
- Title
- Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
- Authors
- Murphy, CT; Lee, SJ; Kenyon, C
- Date Issued
- 2007-11-27
- Publisher
- NATL ACAD SCIENCES
- Abstract
- How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other tissues rises. Here we test the hypothesis that this '' FOXO-to-FOXO '' signaling occurs via feedback regulation of ins-7 insulin gene expression. We find that DAF-16 regulates ins-7 expression in the intestine, and that preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues. Our findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity among the tissues, and they establish the intestine, which is the animal's entire endoderm, as an important insulin-signaling center.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/12742
- DOI
- 10.1073/PNAS.0709613104
- ISSN
- 0027-8424
- Article Type
- Article
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, no. 48, page. 19046 - 19050, 2007-11-27
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