In vivo accumulation of T cells in response to IL-2/anti-IL-2 mAb complexes is dependent in part on the TNF family ligand 4-1BBL
SCIE
SCOPUS
- Title
- In vivo accumulation of T cells in response to IL-2/anti-IL-2 mAb complexes is dependent in part on the TNF family ligand 4-1BBL
- Authors
- Lin, GHY; Stone, JC; Surh, CD; Watts, TH
- Date Issued
- 2012-08
- Publisher
- Nature Publishing Group
- Abstract
- Immune complexes combining IL-2 with particular anti-IL-2 antibodies can be used to selectively expand regulatory T cells or memory T cells. Combining IL-2 with anti-IL-2 (Clone S4B6) greatly enhances the biological potency of IL-2 in vivo leading to selective expansion of CD8 memory T cells and NK cells compared with regulatory T cells. Here we show that in vivo administration of IL-2/anti-IL-2 mAb (IL-2/mAb) complexes induces 4-1BB expression on both adoptively transferred antigenspecific memory CD8 T cells as well as on endogenous memory phenotype cells. Remarkably, the accumulation of adoptively transferred memory CD8 T cells following in vivo IL-2/mAb-complex treatment was found to be dependent in part on the presence of 4-1BBL in the host. These effects were independent of IL-2-induced cell division, suggesting that 4-1BBL-induced survival signals contribute to IL-2/mAb-complex-induced T-cell accumulation in vivo. Immunology and Cell Biology (2012) 90, 743-747; doi:10.1038/icb.2011.83; published online 27 September 2011
- Keywords
- IL-2-antibody complex; therapy; 4-1BBL; CD137; T cell; SELECTIVE STIMULATION; IMMUNE-COMPLEXES; BIM MODULATION; IL-2 RECEPTOR; CUTTING EDGE; GAMMA-CHAIN; SURVIVAL; IMMUNOTHERAPY; COSTIMULATION; LYMPHOCYTES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14769
- DOI
- 10.1038/ICB.2011.83
- ISSN
- 1440-1711
- Article Type
- Article
- Citation
- Immunology and Cell Biology, vol. 90, no. 7, page. 743 - 747, 2012-08
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