N-substituted-3-arylpyrrolidines: Potent and selective ligands at serotonin 1A receptor
SCIE
SCOPUS
- Title
- N-substituted-3-arylpyrrolidines: Potent and selective ligands at serotonin 1A receptor
- Authors
- Ahn, KH; Lee, SJ; Lee, CH; Hong, CY; Park, TK
- Date Issued
- 1999-05-17
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- 3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-[(N-saccharino)butyl]pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents. (C) 1999 Elsevier Science Ltd. All rights reserved.
- Keywords
- ENANTIOSELECTIVE SYNTHESIS; ANTIDEPRESSANT; PYRROLIDINES; ABT-200; AGENTS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/20405
- DOI
- 10.1016/S0960-894X(99)00201-2
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 10, page. 1379 - 1384, 1999-05-17
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- There are no files associated with this item.
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