Synthesis and bioactivities of steroid derivatives as antifungal agents
SCIE
SCOPUS
- Title
- Synthesis and bioactivities of steroid derivatives as antifungal agents
- Authors
- Chung, SK; Ryoo, CH; Yang, HW; Shim, JY; Kang, MG; Lee, KW; Kang, HI
- Date Issued
- 1998-12-24
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- A series of lanosterol and cholesterol derivatives with modified side chain structures, which might interfere with sterol C24-methyltransferase in the ergosterol biosynthesis as substrate analogs, have been synthesized. The in vitro bioassay studies have shown that some of these compounds, in particular with C24-amino- and thio-functionalities, possess potent antifungal activities. in vivo. Bioassays have also been carried out for the leading compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.
- Keywords
- DELTA-24-STEROL METHYLTRANSFERASE; SACCHAROMYCES-CEREVISIAE; ENZYME INACTIVATORS; METHYL TRANSFERASE; CANDIDA-ALBICANS; MECHANISM; BIOSYNTHESIS; INHIBITORS; CATALYSIS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/20575
- DOI
- 10.1016/S0040-4020(98)01000-X
- ISSN
- 0040-4020
- Article Type
- Article
- Citation
- TETRAHEDRON, vol. 54, no. 52, page. 15899 - 15914, 1998-12-24
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- There are no files associated with this item.
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