DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, MC | - |
dc.contributor.author | Koo, BK | - |
dc.contributor.author | Moon, JS | - |
dc.contributor.author | Kim, YY | - |
dc.contributor.author | Park, KC | - |
dc.contributor.author | Kim, NS | - |
dc.contributor.author | Kwon, MY | - |
dc.contributor.author | Kong, MP | - |
dc.contributor.author | Yoon, KJ | - |
dc.contributor.author | Im, SK | - |
dc.contributor.author | Ghim, J | - |
dc.contributor.author | Han, YM | - |
dc.contributor.author | Jang, SK | - |
dc.contributor.author | Shong, M | - |
dc.contributor.author | Kong, YY | - |
dc.date.accessioned | 2016-04-01T01:25:42Z | - |
dc.date.available | 2016-04-01T01:25:42Z | - |
dc.date.created | 2009-08-19 | - |
dc.date.issued | 2008-02-20 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.other | 2008-OAK-0000007542 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22906 | - |
dc.description.abstract | Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor that performs a broad spectrum of biological functions in response to various stimuli. However, no specific coactivator that regulates the transcriptional activity of STAT3 has been identified. Here we report that CR6-interacting factor 1 (Crif1) is a specific transcriptional coactivator of STAT3, but not of STAT1 or STAT5a. Crif1 interacts with STAT3 and positively regulates its transcriptional activity. Crif1(-/-) embryos were lethal around embryonic day 6.5, and manifested developmental arrest accompanied with defective proliferation and massive apoptosis. The expression of STAT3 target genes was markedly reduced in a Crif1(-/-) blastocyst culture and in Oncostatin M-stimulated Crif1-deficient MEFs. Importantly, the key activities of constitutively active STAT3-C, such as transcription, DNA binding, and cellular transformation, were abolished in the Crif1-null MEFs, suggesting the essential role of Crif1 in the transcriptional activity of STAT3. Our results reveal that Crif1 is a novel and essential transcriptional coactivator of STAT3 that modulates its DNA binding ability, and shed light on the regulation of oncogenic STAT3. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.subject | Crif1 | - |
dc.subject | embryogenesis | - |
dc.subject | STAT3 | - |
dc.subject | transcriptional coactivator | - |
dc.subject | tumorigenesis | - |
dc.subject | CR6-INTERACTING FACTOR-1 INTERACTS | - |
dc.subject | COILED-COIL DOMAIN | - |
dc.subject | FUNCTIONAL INTERACTION | - |
dc.subject | TARGETED DISRUPTION | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | MICE LACKING | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEINS | - |
dc.subject | CELLS | - |
dc.subject | GENE | - |
dc.title | Crif1 is a novel transcriptional coactivator of STAT3 | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/sj.emboj.7601986 | - |
dc.author.google | Kwon, MC | - |
dc.author.google | Koo, BK | - |
dc.author.google | Moon, JS | - |
dc.author.google | Kim, YY | - |
dc.author.google | Park, KC | - |
dc.author.google | Kim, NS | - |
dc.author.google | Kwon, MY | - |
dc.author.google | Kong, MP | - |
dc.author.google | Yoon, KJ | - |
dc.author.google | Im, SK | - |
dc.author.google | Ghim, J | - |
dc.author.google | Han, YM | - |
dc.author.google | Jang, SK | - |
dc.author.google | Shong, M | - |
dc.author.google | Kong, YY | - |
dc.relation.volume | 27 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 642 | - |
dc.relation.lastpage | 653 | - |
dc.contributor.id | 10088382 | - |
dc.relation.journal | EMBO JOURNAL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, v.27, no.4, pp.642 - 653 | - |
dc.identifier.wosid | 000253409300006 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 653 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 642 | - |
dc.citation.title | EMBO JOURNAL | - |
dc.citation.volume | 27 | - |
dc.contributor.affiliatedAuthor | Jang, SK | - |
dc.identifier.scopusid | 2-s2.0-39449123058 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 39 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CR6-INTERACTING FACTOR-1 INTERACTS | - |
dc.subject.keywordPlus | COILED-COIL DOMAIN | - |
dc.subject.keywordPlus | FUNCTIONAL INTERACTION | - |
dc.subject.keywordPlus | TARGETED DISRUPTION | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Crif1 | - |
dc.subject.keywordAuthor | embryogenesis | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | transcriptional coactivator | - |
dc.subject.keywordAuthor | tumorigenesis | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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