UVRAG - A new player in autophagy and tumor cell growth
SCIE
SCOPUS
- Title
- UVRAG - A new player in autophagy and tumor cell growth
- Authors
- Liang, CY; Feng, PH; Ku, BS; Oh, BH; Jung, JU
- Date Issued
- 2007-01
- Publisher
- LANDES BIOSCIENCE
- Abstract
- Autophagy has a well-documented role in the maintenance of homeostasis and the response to stressful environments and it is often deregulated in various human diseases including cancer. The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway. Previous studies(1) have demonstrated that Beclin 1-PI3KC3-mediated autophagy is negatively regulated by a proto-oncogene Bcl-2. We have recently identified a novel coiled-coil UVRAG tumor suppressor candidate, which positively engages in Beclin 1-dependent autophagy. UVRAG interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenesis. This finding adds a new player to the emerging picture of the autophagy network, underscoring the importance of the coordinated activity between Bcl-2 and UVRAG in the regulation of Beclin 1-PI3KC3-mediated autophagy and tumor cell control.
- Keywords
- UVRAG; autophagy; tumor suppression; Beclin 1; Bcl-2; COLON-CANCER; GENE; BECLIN-1; INHIBITION; SUPPRESSOR; PROTEIN; CLONING
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/23619
- DOI
- 10.4161/auto.3437
- ISSN
- 1554-8627
- Article Type
- Article
- Citation
- AUTOPHAGY, vol. 3, no. 1, page. 69 - 71, 2007-01
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- There are no files associated with this item.
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