DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, Y | - |
dc.contributor.author | Kim, HS | - |
dc.contributor.author | Joo, Y | - |
dc.contributor.author | Choi, Y | - |
dc.contributor.author | Chang, KA | - |
dc.contributor.author | Park, CH | - |
dc.contributor.author | Shin, KY | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Cheon, YH | - |
dc.contributor.author | Baik, TK | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Suh, YH | - |
dc.date.accessioned | 2016-04-01T01:46:12Z | - |
dc.date.available | 2016-04-01T01:46:12Z | - |
dc.date.created | 2009-08-10 | - |
dc.date.issued | 2007-01 | - |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.other | 2007-OAK-0000006457 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23663 | - |
dc.description.abstract | Amyloid precursor protein (APP) is a member of a gene family that includes two APP-like proteins, APLP1 and 2. Recently, it has been reported that APLP1 and 2 undergo presenilin-dependent gamma-secretase cleavage, as does APP, resulting in the release of an similar to 6 kDa intracellular C-terminal domain (ICD), which can translocate into the nucleus. In this study, we demonstrate that the APLP2-ICDs interact with CP2/LSF/LBP1 (CP2) transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3 beta (GSK-3 beta), which has broad-ranged substrates such as tau- and beta-catenin. The significance of this finding is substantiated by the in vivo evidence of the increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2, and for GSK-3 beta in the AD patients' brain. Taken together, these results suggest that APLP2-ICDs contribute to the AD pathogenesis, by inducing GSK-3 beta expression through the interaction with CP2 transcription factor in the nucleus. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | CELL DEATH AND DIFFERENTIATION | - |
dc.subject | amyloid precursor-like protein 2 | - |
dc.subject | Alzheimer&apos | - |
dc.subject | s disease | - |
dc.subject | CP2 transcription factor | - |
dc.subject | Fe65 | - |
dc.subject | GSK-3 beta | - |
dc.subject | tau | - |
dc.subject | LBP-1C/CP2/LSF GENE POLYMORPHISM | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | ALPHA-SYNUCLEIN | - |
dc.subject | TERMINAL DOMAIN | - |
dc.subject | TAU | - |
dc.subject | APLP2 | - |
dc.subject | APP | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ASSOCIATION | - |
dc.subject | FAMILY | - |
dc.title | Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3 beta expression | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/sj.cdd.4401928 | - |
dc.author.google | Xu, Y | - |
dc.author.google | Kim, HS | - |
dc.author.google | Joo, Y | - |
dc.author.google | Choi, Y | - |
dc.author.google | Chang, KA | - |
dc.author.google | Park, CH | - |
dc.author.google | Shin, KY | - |
dc.author.google | Kim, S | - |
dc.author.google | Cheon, YH | - |
dc.author.google | Baik, TK | - |
dc.author.google | Kim, JH | - |
dc.author.google | Suh, YH | - |
dc.relation.volume | 14 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 79 | - |
dc.relation.lastpage | 91 | - |
dc.contributor.id | 10114767 | - |
dc.relation.journal | CELL DEATH AND DIFFERENTIATION | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELL DEATH AND DIFFERENTIATION, v.14, no.1, pp.79 - 91 | - |
dc.identifier.wosid | 000242850600010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 91 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 79 | - |
dc.citation.title | CELL DEATH AND DIFFERENTIATION | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.identifier.scopusid | 2-s2.0-33845476067 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 29 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LBP-1C/CP2/LSF GENE POLYMORPHISM | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | TERMINAL DOMAIN | - |
dc.subject.keywordPlus | TAU | - |
dc.subject.keywordPlus | APLP2 | - |
dc.subject.keywordPlus | APP | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | amyloid precursor-like protein 2 | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | CP2 transcription factor | - |
dc.subject.keywordAuthor | Fe65 | - |
dc.subject.keywordAuthor | GSK-3 beta | - |
dc.subject.keywordAuthor | tau | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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