Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3 beta expression
SCIE
SCOPUS
- Title
- Intracellular domains of amyloid precursor-like protein 2 interact with CP2 transcription factor in the nucleus and induce glycogen synthase kinase-3 beta expression
- Authors
- Xu, Y; Kim, HS; Joo, Y; Choi, Y; Chang, KA; Park, CH; Shin, KY; Kim, S; Cheon, YH; Baik, TK; Kim, JH; Suh, YH
- Date Issued
- 2007-01
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Amyloid precursor protein (APP) is a member of a gene family that includes two APP-like proteins, APLP1 and 2. Recently, it has been reported that APLP1 and 2 undergo presenilin-dependent gamma-secretase cleavage, as does APP, resulting in the release of an similar to 6 kDa intracellular C-terminal domain (ICD), which can translocate into the nucleus. In this study, we demonstrate that the APLP2-ICDs interact with CP2/LSF/LBP1 (CP2) transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3 beta (GSK-3 beta), which has broad-ranged substrates such as tau- and beta-catenin. The significance of this finding is substantiated by the in vivo evidence of the increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2, and for GSK-3 beta in the AD patients' brain. Taken together, these results suggest that APLP2-ICDs contribute to the AD pathogenesis, by inducing GSK-3 beta expression through the interaction with CP2 transcription factor in the nucleus.
- Keywords
- amyloid precursor-like protein 2; Alzheimer' s disease; CP2 transcription factor; Fe65; GSK-3 beta; tau; LBP-1C/CP2/LSF GENE POLYMORPHISM; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; TERMINAL DOMAIN; TAU; APLP2; APP; PHOSPHORYLATION; ASSOCIATION; FAMILY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/23663
- DOI
- 10.1038/sj.cdd.4401928
- ISSN
- 1350-9047
- Article Type
- Article
- Citation
- CELL DEATH AND DIFFERENTIATION, vol. 14, no. 1, page. 79 - 91, 2007-01
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