DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kaneko, T | - |
dc.contributor.author | Yano, T | - |
dc.contributor.author | Aggarwal, K | - |
dc.contributor.author | Lim, JH | - |
dc.contributor.author | Ueda, K | - |
dc.contributor.author | Oshima, Y | - |
dc.contributor.author | Peach, C | - |
dc.contributor.author | Erturk-Hasdemir, D | - |
dc.contributor.author | Goldman, WE | - |
dc.contributor.author | Oh, BH | - |
dc.contributor.author | Kurata, S | - |
dc.contributor.author | Silverman, N | - |
dc.date.accessioned | 2016-04-01T01:54:32Z | - |
dc.date.available | 2016-04-01T01:54:32Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.other | 2006-OAK-0000006000 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23975 | - |
dc.description.abstract | Drosophila rely entirely on an innate immune response to combat microbial infection. Diaminopimelic acid-containing peptidoglycan, produced by Gram-negative bacteria, is recognized by two receptors, PGRP-LC and PGRP-LE, and activates a homolog of transcription factor NF-kappa B through the Imd signaling pathway. Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface. Interaction with the imd signaling protein was not required for PGRP-LC signaling. Instead, PGRP-LC and PGRP-LE signaled through a receptor-interacting protein homotypic interaction motif-like motif. These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE IMMUNOLOGY | - |
dc.subject | PATTERN-RECOGNITION RECEPTOR | - |
dc.subject | IMD-PATHWAY | - |
dc.subject | BORDETELLA-PERTUSSIS | - |
dc.subject | TRACHEAL CYTOTOXIN | - |
dc.subject | IN-VITRO | - |
dc.subject | PROTEIN | - |
dc.subject | ACTIVATION | - |
dc.subject | COMPLEX | - |
dc.subject | IDENTIFICATION | - |
dc.subject | MELANOGASTER | - |
dc.title | PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/ni1356 | - |
dc.author.google | "Kaneko, T | - |
dc.author.google | Yano, T | - |
dc.author.google | Aggarwal, K | - |
dc.author.google | Lim, JH | - |
dc.author.google | Ueda, K | - |
dc.author.google | Oshima, Y | - |
dc.author.google | Peach, C | - |
dc.author.google | Erturk-Hasdemir, D | - |
dc.author.google | Goldman, WE | - |
dc.author.google | Oh, BH | - |
dc.author.google | Kurata, S | - |
dc.author.google | Silverman, N" | - |
dc.relation.issue | 7 | - |
dc.relation.startpage | 715 | - |
dc.relation.lastpage | 723 | - |
dc.relation.journal | NATURE IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE IMMUNOLOGY, v.7, no.7, pp.715 - 723 | - |
dc.identifier.wosid | 000238377700016 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 723 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 715 | - |
dc.citation.title | NATURE IMMUNOLOGY | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Oh, BH | - |
dc.identifier.scopusid | 2-s2.0-33745225236 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 193 | - |
dc.description.scptc | 188 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PATTERN-RECOGNITION RECEPTOR | - |
dc.subject.keywordPlus | IMD-PATHWAY | - |
dc.subject.keywordPlus | BORDETELLA-PERTUSSIS | - |
dc.subject.keywordPlus | TRACHEAL CYTOTOXIN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MELANOGASTER | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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