PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
SCIE
SCOPUS
- Title
- PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
- Authors
- Kaneko, T; Yano, T; Aggarwal, K; Lim, JH; Ueda, K; Oshima, Y; Peach, C; Erturk-Hasdemir, D; Goldman, WE; Oh, BH; Kurata, S; Silverman, N
- Date Issued
- 2006-07
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Drosophila rely entirely on an innate immune response to combat microbial infection. Diaminopimelic acid-containing peptidoglycan, produced by Gram-negative bacteria, is recognized by two receptors, PGRP-LC and PGRP-LE, and activates a homolog of transcription factor NF-kappa B through the Imd signaling pathway. Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface. Interaction with the imd signaling protein was not required for PGRP-LC signaling. Instead, PGRP-LC and PGRP-LE signaled through a receptor-interacting protein homotypic interaction motif-like motif. These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition.
- Keywords
- PATTERN-RECOGNITION RECEPTOR; IMD-PATHWAY; BORDETELLA-PERTUSSIS; TRACHEAL CYTOTOXIN; IN-VITRO; PROTEIN; ACTIVATION; COMPLEX; IDENTIFICATION; MELANOGASTER
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/23975
- DOI
- 10.1038/ni1356
- ISSN
- 1529-2908
- Article Type
- Article
- Citation
- NATURE IMMUNOLOGY, vol. 7, no. 7, page. 715 - 723, 2006-07
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