DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Lee, WH | - |
dc.contributor.author | Choi, EJ | - |
dc.contributor.author | Choi, JP | - |
dc.contributor.author | Heo, YJ | - |
dc.contributor.author | Gho, YS | - |
dc.contributor.author | Jee, YK | - |
dc.contributor.author | Oh, YM | - |
dc.contributor.author | Kim, YK | - |
dc.date.accessioned | 2016-04-01T07:48:44Z | - |
dc.date.available | 2016-04-01T07:48:44Z | - |
dc.date.created | 2015-06-22 | - |
dc.date.issued | 2015-04-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2015-OAK-0000033039 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26899 | - |
dc.description.abstract | Recent evidence indicates that Gram-negative bacteria-derived extracellular vesicles (EVs) in indoor dust can evoke neutrophilic pulmonary inflammation, which is a key pathology of chronic obstructive pulmonary disease (COPD). Escherichia coli is a ubiquitous bacterium present in indoor dust and secretes nanometer-sized vesicles into the extracellular milieu. In the current study, we evaluated the role of E. coli-derived EVs on the development of COPD, such as emphysema. E. coli EVs were prepared by sequential ultrafiltration and ultracentrifugation. COPD phenotypes and immune responses were evaluated in C57BL/6 wild-type (WT), IFN-gamma-deficient, or IL-17A-deficient mice after airway exposure to E. coli EVs. The present study showed that indoor dust from a bed mattress harbors E. coli EVs. Airway exposure to E. coli EVs increased the production of proinflammatory cytokines, such as TNF-alpha and IL-6. In addition, the repeated inhalation of E. coli EVs for 4 wk induced neutrophilic inflammation and emphysema, which are associated with enhanced elastase activity. Emphysema and elastase activity enhanced by E. coli EVs were reversed by the absence of IFN-gamma or IL-17A genes. In addition, during the early period, lung inflammation is dependent on IL-17A and TNF-alpha, but not on IFN-gamma, and also on TLR4. Moreover, the production of IFN-gamma is eliminated by the absence of IL-17A, whereas IL-17A production is not abolished by IFN-gamma absence. Taken together, the present data suggest that E. coli-derived EVs induce IL-17A-dependent neutrophilic inflammation and thereby emphysema, possibly via upregulation of elastase activity. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Association of Immunologists | - |
dc.relation.isPartOf | Journal of Immunology | - |
dc.title | Extracellular Vesicles Derived from Gram-Negative Bacteria, such as Escherichia coli, Induce Emphysema Mainly via IL-17A-Mediated Neutrophilic Inflammation | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/JIMMUNOL.1402268 | - |
dc.author.google | Kim, YS | - |
dc.author.google | Lee, WH | - |
dc.author.google | Choi, EJ | - |
dc.author.google | Choi, JP | - |
dc.author.google | Heo, YJ | - |
dc.author.google | Gho, YS | - |
dc.author.google | Jee, YK | - |
dc.author.google | Oh, YM | - |
dc.author.google | Kim, YK | - |
dc.relation.volume | 194 | - |
dc.relation.issue | 7 | - |
dc.relation.startpage | 3361 | - |
dc.relation.lastpage | 3368 | - |
dc.contributor.id | 10138843 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of Immunology, v.194, no.7, pp.3361 - 3368 | - |
dc.identifier.wosid | 000351663400041 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 3368 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3361 | - |
dc.citation.title | Journal of Immunology | - |
dc.citation.volume | 194 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.identifier.scopusid | 2-s2.0-84925849059 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 16 | - |
dc.description.scptc | 13 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | OUTER-MEMBRANE VESICLES | - |
dc.subject.keywordPlus | TH17 CELL RESPONSES | - |
dc.subject.keywordPlus | ALLERGEN SENSITIZATION | - |
dc.subject.keywordPlus | PULMONARY INFLAMMATION | - |
dc.subject.keywordPlus | ENDOTOXIN EXPOSURE | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | KEY MEDIATOR | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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