DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Murphy, CT | - |
dc.contributor.author | Kenyon, C | - |
dc.date.accessioned | 2016-04-01T08:15:39Z | - |
dc.date.available | 2016-04-01T08:15:39Z | - |
dc.date.created | 2010-02-17 | - |
dc.date.issued | 2009-11-04 | - |
dc.identifier.issn | 1550-4131 | - |
dc.identifier.other | 2009-OAK-0000019902 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27577 | - |
dc.description.abstract | Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on life span itself. We found that adding a small amount of glucose to the medium (2%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the downregulation of an aquaporin glycerol channel, aqp-1. We show that changes in glycerol metabolism are likely to underlie the life span-shortening effect of glucose and that aqp-1 may act cell nonautonomously as a feedback regulator in the insulin/IGF-1-signaling pathway. Insulin downregulates similar glycerol channels in mammals, suggesting that this glucose-responsive pathway might be conserved evolutionarily. Together, these findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CELL METABOLISM | - |
dc.subject | HEAT-SHOCK FACTOR | - |
dc.subject | NEMATODE CAENORHABDITIS-ELEGANS | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | GLYCEROL CHANNEL | - |
dc.subject | HUMAN LONGEVITY | - |
dc.subject | STRESS RESISTANCE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | PROTEIN DAF-16 | - |
dc.subject | GLYCEMIC INDEX | - |
dc.subject | INSULIN | - |
dc.title | Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression | - |
dc.type | Article | - |
dc.contributor.college | 정보전자융합공학부 | - |
dc.identifier.doi | 10.1016/J.CMET.2009. | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Murphy, CT | - |
dc.author.google | Kenyon, C | - |
dc.relation.volume | 10 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 379 | - |
dc.relation.lastpage | 391 | - |
dc.contributor.id | 10201212 | - |
dc.relation.journal | CELL METABOLISM | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELL METABOLISM, v.10, no.5, pp.379 - 391 | - |
dc.identifier.wosid | 000271498700007 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 391 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 379 | - |
dc.citation.title | CELL METABOLISM | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Lee, SJ | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 154 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HEAT-SHOCK FACTOR | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | GLYCEROL PERMEABILITY | - |
dc.subject.keywordPlus | STRESS RESISTANCE | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | GLYCEMIC INDEX | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | ADIPOSE | - |
dc.subject.keywordPlus | DAF-2 | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
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