Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression
SCIE
SCOPUS
- Title
- Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression
- Authors
- Lee, SJ; Murphy, CT; Kenyon, C
- Date Issued
- 2009-11-04
- Publisher
- CELL PRESS
- Abstract
- Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on life span itself. We found that adding a small amount of glucose to the medium (2%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. This effect involved the downregulation of an aquaporin glycerol channel, aqp-1. We show that changes in glycerol metabolism are likely to underlie the life span-shortening effect of glucose and that aqp-1 may act cell nonautonomously as a feedback regulator in the insulin/IGF-1-signaling pathway. Insulin downregulates similar glycerol channels in mammals, suggesting that this glucose-responsive pathway might be conserved evolutionarily. Together, these findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms.
- Keywords
- HEAT-SHOCK FACTOR; NEMATODE CAENORHABDITIS-ELEGANS; SIGNALING PATHWAY; GLYCEROL CHANNEL; HUMAN LONGEVITY; STRESS RESISTANCE; OXIDATIVE STRESS; PROTEIN DAF-16; GLYCEMIC INDEX; INSULIN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/27577
- DOI
- 10.1016/J.CMET.2009.
- ISSN
- 1550-4131
- Article Type
- Article
- Citation
- CELL METABOLISM, vol. 10, no. 5, page. 379 - 391, 2009-11-04
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