DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, H | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Suzuki, E | - |
dc.contributor.author | Dugan, KD | - |
dc.contributor.author | Stoddard, A | - |
dc.contributor.author | Li, HS | - |
dc.contributor.author | Chodosh, LA | - |
dc.contributor.author | Montell, C | - |
dc.date.accessioned | 2016-04-01T08:15:54Z | - |
dc.date.available | 2016-04-01T08:15:54Z | - |
dc.date.created | 2016-02-15 | - |
dc.date.issued | 2004-02-25 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.other | 2004-OAK-0000019890 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27586 | - |
dc.description.abstract | The Drosophila visual system has provided a model to study phototransduction and retinal degeneration. To identify new candidate proteins that contribute to these processes, we conducted a genome-wide screen for genes expressed predominately in the eye, using DNA microarrays. This screen appeared to be comprehensive as it led to the identification of all 22 eye-enriched genes previously shown to function in phototransduction or implicated in retinal degeneration. In addition, we identified 93 eye-enriched genes whose roles have not been previously defined. One of the eye-enriched genes encoded a member of a large family of transmembrane proteins, referred to as tetraspanins. We created a null mutation in the eye-enriched tetraspanin, Sunglasses (Sun), which resulted in light-induced retinal degeneration. We found that the Sun protein was distributed primarily in lysosomes, and functioned in a long-known but poorly understood phenomenon of light-induced degradation of rhodopsin. We propose that lysosomal tetraspanins in mammalian cells may also function in the downregulation of rhodopsin and other G-protein-coupled receptors, in response to intense or prolonged agonist stimulation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | European Molecular Biology Organization Press | - |
dc.relation.isPartOf | The EMBO Journal | - |
dc.subject | Drosophila | - |
dc.subject | microarray | - |
dc.subject | phototransduction | - |
dc.subject | retinal degeneration | - |
dc.subject | rhodopsin | - |
dc.subject | tetraspanin | - |
dc.subject | DROSOPHILA-MELANOGASTER | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | PHOTORECEPTOR CELLS | - |
dc.subject | PROTEIN | - |
dc.subject | ARRESTIN | - |
dc.subject | COMPLEX | - |
dc.subject | CDNA | - |
dc.subject | INAD | - |
dc.subject | TRP | - |
dc.subject | TRANSLOCATION | - |
dc.title | A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen | - |
dc.type | Article | - |
dc.contributor.college | 정보전자융합공학부 | - |
dc.identifier.doi | 10.1038/sj.emboj.7600112 | - |
dc.author.google | Xu, H | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Suzuki, E | - |
dc.author.google | Dugan, KD | - |
dc.author.google | Stoddard, A | - |
dc.author.google | Li, HS | - |
dc.author.google | Chodos | - |
dc.relation.volume | 23 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 811 | - |
dc.relation.lastpage | 822 | - |
dc.contributor.id | 10201212 | - |
dc.relation.journal | EMBO JOURNAL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | The EMBO Journal, v.23, no.4, pp.811 - 822 | - |
dc.identifier.wosid | 000220694100014 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 822 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 811 | - |
dc.citation.title | The EMBO Journal | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Lee, SJ | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 78 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PHOTORECEPTOR CELLS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ARRESTIN | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | CDNA | - |
dc.subject.keywordPlus | INAD | - |
dc.subject.keywordPlus | TRP | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordAuthor | Drosophila | - |
dc.subject.keywordAuthor | microarray | - |
dc.subject.keywordAuthor | phototransduction | - |
dc.subject.keywordAuthor | retinal degeneration | - |
dc.subject.keywordAuthor | rhodopsin | - |
dc.subject.keywordAuthor | tetraspanin | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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