A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in Aplysia
SCIE
SCOPUS
- Title
- A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in Aplysia
- Authors
- Si, K; Giustetto, M; Etkin, A; Hsu, R; Janisiewicz, AM; Miniaci, MC; Kim, JH; Zhu, HX; K; el, ER
- Date Issued
- 2003-12-26
- Publisher
- CELL PRESS
- Abstract
- Synapse-specific facilitation requires rapamycin-dependent local protein synthesis at the activated synapse. In Aplysia, rapamycin-dependent local protein synthesis serves two functions: (1) it provides a component of the mark at the activated synapse and thereby confers synapse specificity and (2) it stabilizes the synaptic growth associated with long-term facilitation. Here we report that a neuron-specific isoform of cytoplasmic polyadenylation element binding protein (CPEB) regulates this synaptic protein synthesis in an activity-dependent manner. Aplysia CPEB protein is upregulated locally at activated synapses, and it is needed not for the initiation but for the stable maintenance of long-term facilitation. We suggest that Aplysia CPEB is one of the stabilizing components of the synaptic mark.
- Keywords
- XENOPUS OOCYTE MATURATION; ELEMENT-BINDING PROTEIN; CAMKII MESSENGER-RNA; DROSOPHILA ORB GENE; CYTOPLASMIC POLYADENYLATION; TRANSLATIONAL CONTROL; S6 KINASE; EXPRESSION; PHOSPHORYLATION; POTENTIATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/28382
- DOI
- 10.1016/S0092-8674(03)01021-3
- ISSN
- 0092-8674
- Article Type
- Article
- Citation
- CELL, vol. 115, no. 7, page. 893 - 904, 2003-12-26
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