DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung-Hwan Kim | - |
dc.contributor.author | Eun-Ji Jeun | - |
dc.contributor.author | Chun-Pyo Hong | - |
dc.contributor.author | Seong-Hoon Kim | - |
dc.contributor.author | Min Seong Jang | - |
dc.contributor.author | Eun-Jung Lee | - |
dc.contributor.author | Sook Jin Moon | - |
dc.contributor.author | Chang Ho Yun | - |
dc.contributor.author | Sin-Hyeog Im | - |
dc.contributor.author | Seok-Geun Jeong | - |
dc.contributor.author | Beom-Young Park | - |
dc.contributor.author | KIM, KYONG TAI | - |
dc.contributor.author | Ju-Young Seoh | - |
dc.contributor.author | Yoon-Keun Kim | - |
dc.contributor.author | Sung-Jong Oh | - |
dc.contributor.author | Jun-Sang Ham | - |
dc.contributor.author | YANG, BO GIE | - |
dc.contributor.author | JANG, MYOUNG HO | - |
dc.date.accessioned | 2017-07-19T12:26:46Z | - |
dc.date.available | 2017-07-19T12:26:46Z | - |
dc.date.created | 2016-03-02 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/35830 | - |
dc.description.abstract | Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies. | - |
dc.language | English | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.title | Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/J.JACI.2015.08.016 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.137, no.2, pp.507 - 516 | - |
dc.identifier.wosid | 000369235500020 | - |
dc.date.tcdate | 2019-03-01 | - |
dc.citation.endPage | 516 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 507 | - |
dc.citation.title | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.volume | 137 | - |
dc.contributor.affiliatedAuthor | Sin-Hyeog Im | - |
dc.contributor.affiliatedAuthor | KIM, KYONG TAI | - |
dc.contributor.affiliatedAuthor | YANG, BO GIE | - |
dc.contributor.affiliatedAuthor | JANG, MYOUNG HO | - |
dc.identifier.scopusid | 2-s2.0-84957970327 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.description.scptc | 14 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | OUTER-MEMBRANE VESICLES | - |
dc.subject.keywordPlus | DENDRITIC CELL | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | ANAPHYLAXIS | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.subject.keywordPlus | EXOSOMES | - |
dc.subject.keywordPlus | INFANTS | - |
dc.subject.keywordPlus | COMMENSAL | - |
dc.subject.keywordAuthor | Food allergy | - |
dc.subject.keywordAuthor | Bifidobacterium longum | - |
dc.subject.keywordAuthor | probiotics | - |
dc.subject.keywordAuthor | extracellular vesicle | - |
dc.subject.keywordAuthor | mast cells | - |
dc.subject.keywordAuthor | family 5 extracellular solute-binding protein | - |
dc.subject.keywordAuthor | ovalbumin | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
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