Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression
SCIE
SCOPUS
- Title
- Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression
- Authors
- Jung-Hwan Kim; Eun-Ji Jeun; Chun-Pyo Hong; Seong-Hoon Kim; Min Seong Jang; Eun-Jung Lee; Sook Jin Moon; Chang Ho Yun; Sin-Hyeog Im; Seok-Geun Jeong; Beom-Young Park; KIM, KYONG TAI; Ju-Young Seoh; Yoon-Keun Kim; Sung-Jong Oh; Jun-Sang Ham; YANG, BO GIE; JANG, MYOUNG HO
- Date Issued
- 2016-02
- Publisher
- MOSBY-ELSEVIER
- Abstract
- Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease.
Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies.
Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed.
Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms. Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model.
Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms.
Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/35830
- DOI
- 10.1016/J.JACI.2015.08.016
- ISSN
- 0091-6749
- Article Type
- Article
- Citation
- JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 137, no. 2, page. 507 - 516, 2016-02
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