DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kavitha, T | - |
dc.contributor.author | Kim, JO | - |
dc.contributor.author | Jang, S | - |
dc.contributor.author | KIM, DONG PYO | - |
dc.contributor.author | Kang, IK | - |
dc.contributor.author | Park, SY | - |
dc.date.accessioned | 2017-07-19T12:53:30Z | - |
dc.date.available | 2017-07-19T12:53:30Z | - |
dc.date.created | 2016-12-09 | - |
dc.date.issued | 2016-04-01 | - |
dc.identifier.issn | 0928-4931 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/36612 | - |
dc.description.abstract | A fluorescent thermoresponsive polymer consisting of poly(N-vinylcaprolactam) (PVCL) coupled with carbon dots (CDs) (PVCL-CDs) was synthesized by reacting a carboxyl-terminated PVCL derivative with CDs via N-hydroxysuccinimide and N-(3-(dimethylamino)propyl)-N-ethylcarbodiimide hydrochloride coupling. The temperature-dependent fluorescence properties of this material were studied for biomedical applications. Fluorescence quenching in PVCL-CDs was observed above the lower critical solution temperature (LCST) due to thermo-induced aggregation of the PVCL chains. This fluorescent thermoresponsive PVCL-CDs showed good biocompatibility and was demonstrated as a thermometer for sensing intracellular temperatures and also as a marker for bioimaging. In addition, PVCL-CDs showed a significant fluorescence turn-on response to proteins above the LCST, which allows for the utilization of this material in biosensors. Thus, PVCL-CDs, with its tuneable size, low cytotoxicity, good photostability, ease of bioconjugation, and resistance to metabolic degradation, is a novel material for biomedical applications. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | - |
dc.title | Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/J.MSEC.2015.12.070 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.61, pp.492 - 498 | - |
dc.identifier.wosid | 000370303600060 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 498 | - |
dc.citation.startPage | 492 | - |
dc.citation.title | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | - |
dc.citation.volume | 61 | - |
dc.contributor.affiliatedAuthor | KIM, DONG PYO | - |
dc.identifier.scopusid | 2-s2.0-84953897739 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 17 | - |
dc.description.scptc | 14 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GRAPHENE QUANTUM DOTS | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | HYDRATION | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Thermo-responsive polymer | - |
dc.subject.keywordAuthor | Carbon dot | - |
dc.subject.keywordAuthor | Lower critical solution temperature | - |
dc.subject.keywordAuthor | Biocompatibility | - |
dc.subject.keywordAuthor | Bio-imaging | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
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