Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications
SCIE
SCOPUS
- Title
- Multifaceted thermoresponsive poly(N-vinylcaprolactam) coupled with carbon dots for biomedical applications
- Authors
- Kavitha, T; Kim, JO; Jang, S; KIM, DONG PYO; Kang, IK; Park, SY
- Date Issued
- 2016-04-01
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- A fluorescent thermoresponsive polymer consisting of poly(N-vinylcaprolactam) (PVCL) coupled with carbon dots (CDs) (PVCL-CDs) was synthesized by reacting a carboxyl-terminated PVCL derivative with CDs via N-hydroxysuccinimide and N-(3-(dimethylamino)propyl)-N-ethylcarbodiimide hydrochloride coupling. The temperature-dependent fluorescence properties of this material were studied for biomedical applications. Fluorescence quenching in PVCL-CDs was observed above the lower critical solution temperature (LCST) due to thermo-induced aggregation of the PVCL chains. This fluorescent thermoresponsive PVCL-CDs showed good biocompatibility and was demonstrated as a thermometer for sensing intracellular temperatures and also as a marker for bioimaging. In addition, PVCL-CDs showed a significant fluorescence turn-on response to proteins above the LCST, which allows for the utilization of this material in biosensors. Thus, PVCL-CDs, with its tuneable size, low cytotoxicity, good photostability, ease of bioconjugation, and resistance to metabolic degradation, is a novel material for biomedical applications. (C) 2015 Elsevier B.V. All rights reserved.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/36612
- DOI
- 10.1016/J.MSEC.2015.12.070
- ISSN
- 0928-4931
- Article Type
- Article
- Citation
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 61, page. 492 - 498, 2016-04-01
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