Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy
SCIE
SCOPUS
- Title
- Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy
- Authors
- Lee, C; Kwon, W; Beack, S; Lee, D; Park, Y; Kim, H; Hahn, SK; Rhee, SW; Kim, C
- Date Issued
- 2016-09
- Publisher
- Ivyspring International Publisher
- Abstract
- Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation. However, photostability and safety issues have been the technical hurdles for further clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability. Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at a specific wavelength. We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy. Finally, biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and a degradation test.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/37075
- DOI
- 10.7150/thno.16923
- ISSN
- 1838-7640
- Article Type
- Article
- Citation
- Theranostics, vol. 6, no. 12, page. 2196 - 2208, 2016-09
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