IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection
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SCOPUS
- Title
- IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection
- Authors
- Renkema, KR; Lee, JY; Lee, YJ; Hamilton, SE; Hogquist, KA; Jameson, SC
- Date Issued
- 2016-06-27
- Publisher
- ROCKEFELLER UNIV PRESS
- Abstract
- Previous studies have revealed that a population of innate memory CD8(+) T cells is generated in response to IL-4, first appearing in the thymus and bearing high expression levels of Eomesodermin (Eomes) but not T-bet. However, the antigen specificity and functional properties of these cells is poorly defined. In this study, we show that IL-4 regulates not only the frequency and function of innate memory CD8(+) T cells, but also regulates Eomes expression levels and functional reactivity of naive CD8(+) T cells. Lack of IL-4 responsiveness attenuates the capacity of CD8(+) T cells to mount a robust response to lymphocytic choriomeningitis virus infection, with both quantitative and qualitative effects on effector and memory antigen-specific CD8(+) T cells. Unexpectedly, we found that, although numerically rare, memory phenotype CD8(+) T cells in IL-4R alpha-deficient mice exhibited enhanced reactivity after in vitro and in vivo stimulation. Importantly, our data revealed that these effects of IL-4 exposure occur before, not during, infection. Together, these data show that IL-4 influences the entire peripheral CD8(+) T cell pool, influencing expression of T-box transcription factors, functional reactivity, and the capacity to respond to infection. These findings indicate that IL-4, a canonical Th2 cell cytokine, can sometimes promote rather than impair Th1 cell-type immune responses.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/39263
- DOI
- 10.1084/JEM.20151359
- ISSN
- 0022-1007
- Article Type
- Article
- Citation
- JOURNAL OF EXPERIMENTAL MEDICINE, vol. 213, no. 7, page. 1319 - 1329, 2016-06-27
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