Surface Modification of Magnetic Nanoparticle Clusters for Biomedical Applications
- Title
- Surface Modification of Magnetic Nanoparticle Clusters for Biomedical Applications
- Authors
- KIM, SUNGJEE; LEE, GYUDONG; JEONG, SANGHWA; KWON, DONGHOON; PARK, JOONHYUCK; JEON, SANGMIN
- Date Issued
- 2017-11-28
- Publisher
- MRS
- Abstract
- The diagnosis and therapy of disease require information of multiple targets. In order to identify multiple biomolecule, an effective strategy for separation and multiplexing is important.1) A bio-barcoding system that incorporates quantum dots (QDs) and magnetic nanoparticles can be useful for such applications.2) Silica-shell-coated magnetic nanoparticle cluster (SMNC) were synthesized and the surface of SMNC was decorated by zwitterionic ligands, which made the SMNC colloidally stable at physiological condition and possess minimal non-specific adsorptions.3) Zwitterion tethered SMNC showed enhanced colloidal stability in high salt concentration and under broad pH range. The minimal non-specific adsorption was confirmed by non-specific adsorption level assays using fluorescein conjugated serum albumin. Also, SMNCs were loaded with QDs using amphiphilic polyethyleneimine derivatives (amPEIs). The resultant a few hundred nanometer sized SMNC-QDs-amPEIs were composed of SMNC core surrounded by hundreds of QDs. SMNC-QDs complexs showed excellent photoluminescene(PL) property and can be facilely collected in presence of an external magnetic field. These SMNC-QDs complexs and SMNC with reduced non-specific adsorption can be useful as bio- barcoding agent.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/42689
- Article Type
- Conference
- Citation
- 2017 MRS Fall Meeting & Exhibit, 2017-11-28
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