Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling
SCIE
SCOPUS
- Title
- Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling
- Authors
- Lee, Jae Wook; Ha, Hyung-Ho; Vendrell, Marc; Bork, Jacqueline T.; Chang, Young-Tae
- Date Issued
- 2011
- Publisher
- CSIRO PUBLISHING
- Abstract
- A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling.
- Keywords
- ORTHOGONAL SYNTHESIS; TRIAZINE LIBRARY; ANTITUMOR EVALUATION; KINASE INHIBITORS; SERIES; HETEROCYCLES; DERIVATIVES; MODULATORS; ANALOGS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50213
- DOI
- 10.1071/CH11034
- ISSN
- 0004-9425
- Article Type
- Article
- Citation
- AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 64, no. 5, page. 540 - 544, 2011
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.