Solid-phase Synthesis of Combinatorial 2,4-Disubstituted-1,3,5-Triazine via Amine Nucleophilic Reaction
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- Title
- Solid-phase Synthesis of Combinatorial 2,4-Disubstituted-1,3,5-Triazine via Amine Nucleophilic Reaction
- Authors
- Moon, Sung Won; Ham, Jungyeob; Chang, Young-Tae; Lee, Jae Wook
- Date Issued
- 2015-01
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- We report a solid-phase synthesis of 2,4-diamino-1,3,5-triazines, starting from 2,4-dichloro-1,3,5-triazine captured by resin-bound amines followed by amination and acidic mild cleavage. The derivatives of 22 diamino-1,3,5-triazine compounds were prepared in high purity without extensive reaction conditions.
- Keywords
- TRIAZINE LIBRARY; ORTHOGONAL SYNTHESIS; KINASE INHIBITORS; SERIES; HETEROCYCLES; DERIVATIVES; MODULATORS; CHEMISTRY; ANALOGS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50282
- DOI
- 10.1002/bkcs.10091
- ISSN
- 0253-2964
- Article Type
- Article
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 36, no. 1, page. 435 - 438, 2015-01
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