Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes
SCIE
SCOPUS
- Title
- Real-Time In Vivo Hepatotoxicity Monitoring through Chromophore-Conjugated Photon-Upconverting Nanoprobes
- Authors
- Peng, Juanjuan; Samanta, Animesh; Zeng, Xiao; Han, Sanyang; Wang, Lu; Su, Dongdong; Loong, Daniel Teh Boon; Kang, Nam-Young; Park, Sung-Jin; All, Angelo Homayoun; Jiang, Wenxuan; Yuan, Lin; Liu, Xiaogang; Chang, Young-Tae
- Date Issued
- 2017-04
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- Drug toxicity is a long-standing concern of modern medicine. A typical anti-pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO-. Conventional blood tests fail to offer real-time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore-conjugated upconversion nanoparticles. Upon injection, these nanoprobes mainly accumulate in the liver and the luminescence of nanoparticles remains suppressed owing to energy transfer to the chromophore. ONOO- can readily bleach the chromophore and thus recover the luminescence, the presence of ONOO- in the liver leads to fast restoring of the near-infrared emission. Taking advantages of the high tissue-penetration capability of near-infrared excitation/emission, these nanoprobes achieve real-time monitoring of hepatotoxicity in living animals, thereby providing a convenient screening strategy for assessing hepatotoxicity of synthetic drugs.
- Keywords
- UP-CONVERSION NANOPARTICLES; DRUG-DELIVERY; PROBES; LIVER; PEROXYNITRITE; NANOCRYSTALS; THERAPY; SURFACE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/50357
- DOI
- 10.1002/anie.201612020
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 56, no. 15, page. 4165 - 4169, 2017-04
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