DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Lee, B.J. | - |
dc.contributor.author | Lee, Y.M. | - |
dc.contributor.author | Park, H. | - |
dc.contributor.author | Kim, J.H. | - |
dc.contributor.author | Kim, W.J. | - |
dc.date.accessioned | 2018-07-17T10:46:09Z | - |
dc.date.available | 2018-07-17T10:46:09Z | - |
dc.date.created | 2017-12-21 | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1543-8384 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/92108 | - |
dc.description.abstract | Here, nanoconstructs consisting of a DNA-amplified aptamer with a biocompatible polymer backbone for capturing target biomolecules are presented. First, the polymer-DNA nanoconstructs were prepared by hybridization of two complementary single-stranded DNAs that were each conjugated to a dextran polymer backbone. The designed polymer-DNA amplified aptamer nanoconstructs (PA-aNCs) were then prepared by utilizing polymer-DNA nanoconstructs conjugated with an aptamer (PA-NCs) using a rolling circle amplification reaction to amplify the aptamer. These PA-aNCs were successfully applied to alleviate tumor growth and vascular endothelial growth factor (VEGF)-induced retinal vascular hyperpermeability in vivo through the highly effective capture of human VEGF as a target molecule. These PA-aNCs could be used as therapeutic agent for anti-VEGF therapy by efficiently capturing human VEGF. ? 2017 American Chemical Society. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | MOLECULAR PHARMACEUTICS | - |
dc.subject | aptamer | - |
dc.subject | complementary DNA | - |
dc.subject | dextran | - |
dc.subject | DNA | - |
dc.subject | polymer | - |
dc.subject | single stranded DNA | - |
dc.subject | vasculotropin | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | Article | - |
dc.subject | biocompatibility | - |
dc.subject | blood vessel permeability | - |
dc.subject | conjugation | - |
dc.subject | controlled study | - |
dc.subject | DNA hybridization | - |
dc.subject | gene amplification | - |
dc.subject | growth inhibition | - |
dc.subject | human | - |
dc.subject | human cell | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | priority journal | - |
dc.subject | retina blood vessel | - |
dc.subject | synthesis | - |
dc.subject | tumor growth | - |
dc.title | Self-Assembled Nanoconstructs Modified with Amplified Aptamers Inhibited Tumor Growth and Retinal Vascular Hyperpermeability via Vascular Endothelial Growth Factor Capturing | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.molpharmaceut.6b00949 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR PHARMACEUTICS, v.14, no.5, pp.1460 - 1468 | - |
dc.identifier.wosid | 000400633300014 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1468 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1460 | - |
dc.citation.title | MOLECULAR PHARMACEUTICS | - |
dc.citation.volume | 14 | - |
dc.contributor.affiliatedAuthor | Kim, W.J. | - |
dc.identifier.scopusid | 2-s2.0-85018397688 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ANTI-ANGIOGENIC THERAPY | - |
dc.subject.keywordPlus | DIABETIC-RETINOPATHY | - |
dc.subject.keywordPlus | MACULAR DEGENERATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | PEGAPTANIB | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordAuthor | anti-VEGF therapy | - |
dc.subject.keywordAuthor | DNA nanoconstructs | - |
dc.subject.keywordAuthor | polymer-DNA conjugates | - |
dc.subject.keywordAuthor | antitumor therapy | - |
dc.subject.keywordAuthor | retinal vascular hyperpermeability | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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