DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hye-Ran | - |
dc.contributor.author | Mun, YeVin | - |
dc.contributor.author | Lee, Kyung-Sik | - |
dc.contributor.author | Park, Yoo-Jin | - |
dc.contributor.author | Park, Jeong-Su | - |
dc.contributor.author | Park, Jin-Hwa | - |
dc.contributor.author | Jeon, Bu-Nam | - |
dc.contributor.author | Kim, Chang-Hyun | - |
dc.contributor.author | Jun, Youngsoo | - |
dc.contributor.author | Hyun, Young-Min | - |
dc.contributor.author | Kim, Minsoo | - |
dc.contributor.author | Lee, Sang-Myeong | - |
dc.contributor.author | Park, Chul-Seung | - |
dc.contributor.author | Im, Sin-Hyeog | - |
dc.contributor.author | Jun, Chang-Duk | - |
dc.date.accessioned | 2019-01-28T06:35:24Z | - |
dc.date.available | 2019-01-28T06:35:24Z | - |
dc.date.created | 2018-10-10 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/94628 | - |
dc.description.abstract | Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear. Here we show that antigen-specific T cells deposit membrane particles derived from microvilli onto the surface of cognate antigen-bearing APCs. Microvilli carry T cell receptors (TCR) at all stages of T cell activation and are released as large TCR-enriched, T cell microvilli particles (TMP) in a process of trogocytosis. These microvilli exclusively contain protein arrestin-domain-containing protein 1, which is directly involved in membrane budding and, in combination with vacuolar protein-sorting-associated protein 4, transforms large TMPs into smaller, exosome-sized TMPs. Notably, TMPs from CD4(+) T cells are enriched with LFA-2/CD2 and various cytokines involved in activating dendritic cells. Collectively, these results demonstrate that T cell microvilli constitute "immunological synaptosomes" that carry T cell messages to APCs. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.subject | CD2 antigen | - |
dc.subject | cell membrane protein | - |
dc.subject | retina S antigen | - |
dc.subject | T lymphocyte receptor | - |
dc.subject | unclassified drug | - |
dc.subject | vacuolar protein sorting associated protein 4 | - |
dc.subject | lymphocyte antigen receptor | - |
dc.subject | antigen | - |
dc.subject | cell component | - |
dc.subject | immune system | - |
dc.subject | membrane | - |
dc.subject | protein | - |
dc.subject | animal cell | - |
dc.subject | antigen presenting cell | - |
dc.subject | Article | - |
dc.subject | CD4+ T lymphocyte | - |
dc.subject | cell budding | - |
dc.subject | cell membrane | - |
dc.subject | cell size | - |
dc.subject | cell surface | - |
dc.subject | cell transformation | - |
dc.subject | dendritic cell | - |
dc.subject | exosome | - |
dc.subject | human | - |
dc.subject | human cell | - |
dc.subject | microvillus | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | phenomena and functions of biological membrane | - |
dc.subject | protein expression | - |
dc.subject | synaptosome | - |
dc.subject | T lymphocyte | - |
dc.subject | T lymphocyte activation | - |
dc.subject | trogocytosis | - |
dc.subject | animal | - |
dc.subject | antigen presenting cell | - |
dc.subject | HEK293 cell line | - |
dc.subject | Jurkat cell line | - |
dc.subject | membrane microparticle | - |
dc.subject | metabolism | - |
dc.subject | microvillus | - |
dc.subject | physiology | - |
dc.subject | synaptosome | - |
dc.subject | ultrastructure | - |
dc.subject | Animals | - |
dc.subject | Antigen-Presenting Cells | - |
dc.subject | CD4-Positive T-Lymphocytes | - |
dc.subject | Cell-Derived Microparticles | - |
dc.subject | Dendritic Cells | - |
dc.subject | HEK293 Cells | - |
dc.subject | Humans | - |
dc.subject | Jurkat Cells | - |
dc.subject | Mice | - |
dc.subject | Microvilli | - |
dc.subject | Receptors, Antigen, T-Cell | - |
dc.subject | Synaptosomes | - |
dc.title | T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-018-06090-8 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.9, no.1 | - |
dc.identifier.wosid | 000444014100005 | - |
dc.citation.number | 1 | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Im, Sin-Hyeog | - |
dc.identifier.scopusid | 2-s2.0-85053009411 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | INTERCELLULAR TRANSFER | - |
dc.subject.keywordPlus | LYMPHOCYTE ACTIVATION | - |
dc.subject.keywordPlus | SURFACE MOLECULES | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | B-LYMPHOCYTE | - |
dc.subject.keywordPlus | CLASS-II | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | SYNAPSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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